885 research outputs found
Transient dynamics and momentum redistribution in cold atoms via recoil-induced resonances
We use an optically dense, anisotropic magneto-optical trap to study
recoil-induced resonances (RIRs) in the transient, high-gain regime. We find
that two distinct mechanisms govern the atomic dynamics: the finite,
frequency-dependent atomic response time, and momentum-space population
redistribution. At low input probe intensities, the residual Doppler width of
the atoms, combined with the finite atomic response time, result in a linear,
transient hysteretic effect that modifies the locations, widths, and magnitudes
of the resulting gain spectra depending on the sign of the scan chirp. When
larger intensities (\textit{i.e.}, greater than a few W/cm) are
incident on the atomic sample for several s, hole-burning in the atomic
sample's momentum distribution leads to a coherent population redistribution
that persists for approximately 100 s. We propose using RIRs to engineer
the atomic momentum distribution to enhance the nonlinear atom-photon coupling.
We present a numerical model, and compare the calculated and experimental
results to verify our interpretation.Comment: 7 pages, 6 figure
High-order optical nonlinearity at low light levels
We observe a nonlinear optical process in a gas of cold atoms that
simultaneously displays the largest reported fifth-order nonlinear
susceptibility \chi^(5) = 1.9x10^{-12} (m/V)^4 and high transparency. The
nonlinearity results from the simultaneous cooling and crystallization of the
gas, and gives rise to efficient Bragg scattering in the form of
six-wave-mixing at low-light-levels. For large atom-photon coupling strengths,
the back-action of the scattered fields influences the light-matter dynamics.
This system may have important applications in many-body physics, quantum
information processing, and multidimensional soliton formation.Comment: 5 pages, 3 figure
Can Power from Space Compete?
Satellite solar power (SSP) has been suggested as an alternative to terrestrial energy resources for electricity generation. In this study, we consider the market for electricity from the present to 2020, roughly the year when many experts expect SSP to be technically achievable. We identify several key challenges for SSP in competing with conventional electricity generation in developed and developing countries, discuss the role of market and economic analysis as technical development of SSP continues during the coming years, and suggest future research directions to improve understanding of the potential economic viability of SSP.
All-Optical Switching with Transverse Optical Patterns
We demonstrate an all-optical switch that operates at ultra-low-light levels
and exhibits several features necessary for use in optical switching networks.
An input switching beam, wavelength , with an energy density of
photons per optical cross section [] changes
the orientation of a two-spot pattern generated via parametric instability in
warm rubidium vapor. The instability is induced with less than 1 mW of total
pump power and generates several Ws of output light. The switch is
cascadable: the device output is capable of driving multiple inputs, and
exhibits transistor-like signal-level restoration with both saturated and
intermediate response regimes. Additionally, the system requires an input power
proportional to the inverse of the response time, which suggests thermal
dissipation does not necessarily limit the practicality of optical logic
devices
Design characteristics of the CORRONA CERTAIN study: a comparative effectiveness study of biologic agents for rheumatoid arthritis patients
BACKGROUND: Comparative effectiveness research has recently attracted considerable attention. The Comparative Effectiveness Registry to study Therapies for Arthritis and Inflammatory Conditions (CERTAIN) is an ongoing prospective cohort study of adult patients with Rheumatoid Arthritis (RA).
METHODS/DESIGN: CERTAIN uses the existing Consortium of Rheumatology Researchers of North America (CORRONA) network of participating private and academic sites in order to recruit patients fulfilling the 1987 ACR criteria that have at least moderate disease activity. Patients starting or switching biologic agents either anti-TNF therapy or a non anti-TNF biologic are eligible for enrollment, depending on the treatment selected by their physician. Enrollment is expected to be completed by March of 2014, and 2711 patients will participate in the study. As of October 7th 2013, 2234 patients have been enrolled. Patient visits and laboratory blood work are mandated every three months for one year. Safety data is collected through one year and beyond. The primary comparative effectiveness endpoint is attainment of low RA disease activity at one year among patients who have been exposed to at least one prior TNF-alpha inhibitor agent prior to enrollment. Multiple secondary effectiveness and safety endpoints will be addressed by investigating the entire population enrolled (naive and biologic experienced).
DISCUSSION: The unique design features of CERTAIN will inform comparative effectiveness and safety questions for choosing biologic agents for the management of RA
Hydroxychloroquine and the risk of respiratory infections among RA patients
OBJECTIVES: To determine the effect of hydroxychloroquine on the incidence of new respiratory infections in a large registry of rheumatoid arthritis (RA) patients compared with a matched cohort receiving other conventional disease-modifying antirheumatic drugs (csDMARDs).
METHODS: We reviewed physician-reported infections including upper respiratory infections (URI), bronchitis and pneumonia in the Corrona RA registry from June 2008 to February 2020 with the goal of comparing infections in biologic/targeted synthetic (b/ts) DMARDs naive HCQ starts compared with starts of other csDMARDs and no HCQ. Patients on different interventions were compared using time-varying adjusted Cox models adjusting for age, sex, duration of RA, BMI, disease activity, smoking status, concurrent medications, season of the year, year of onset and history of serious infections, diabetes or cardiovascular disease (CVD). A secondary analysis in a set of propensity-matched starts were also compared adjusting for time-varying covariates. The analysis was repeated including URI and bronchitis only and also for serious respiratory infections only.
RESULTS: No evidence of differences was found in the incidence of any respiratory infection (URI, bronchitis, pneumonia) in patients receiving HCQ compared with other csDMARDs: HR=0.87 (0.70 to1.07) in adjusted analyses and HR=0.90 (0.70 to 1.17) in adjusted matched analysis. Similar results were found in the analysis of URI and bronchitis only and for serious respiratory infections only.
CONCLUSIONS: In patients with RA, the risk for respiratory infections was similar among patients using HCQ as compared to other non-biologic DMARDs
A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk
Background: There is currently great interest in the incorporation of genetic susceptibility loci into screening models to identify individuals at high risk of disease. Here, we present the first risk prediction model including all 46 known genetic loci associated with rheumatoid arthritis (RA). Methods: A weighted genetic risk score (wGRS) was created using 45 RA non-human leucocyte antigen (HLA) susceptibility loci, imputed amino acids at HLA-DRB1 (11, 71 and 74), HLA-DPB1 (position 9) HLA-B (position 9) and gender. The wGRS was tested in 11 366 RA cases and 15 489 healthy controls. The risk of developing RA was estimated using logistic regression by dividing the wGRS into quintiles. The ability of the wGRS to discriminate between cases and controls was assessed by receiver operator characteristic analysis and discrimination improvement tests. Results: Individuals in the highest risk group showed significantly increased odds of developing anti-cyclic citrullinated peptide-positive RA compared to the lowest risk group (OR 27.13, 95% CI 23.70 to 31.05). The wGRS was validated in an independent cohort that showed similar results (area under the curve 0.78, OR 18.00, 95% CI 13.67 to 23.71). Comparison of the full wGRS with a wGRS in which HLA amino acids were replaced by a HLA tag single-nucleotide polymorphism showed a significant loss of sensitivity and specificity. Conclusions: Our study suggests that in RA, even when using all known genetic susceptibility variants, prediction performance remains modest; while this is insufficiently accurate for general population screening, it may prove of more use in targeted studies. Our study has also highlighted the importance of including HLA variation in risk prediction models
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